A prediction of the tertiary structure of human phospholipase A2 from synovial fluid and a model of substrate binding

M Kelly, RB Sessions, H Muirhead

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The tertiary structure of human Phospholipase A2 (PLA2) from synovial fluid has been predicted by modelling the sequence onto the structure of the homologous snake venom PLA2 structure (Crotalus atrox). A model of substrate binding to the protein has been developed based on the predicted structure of the apoenzyme. These modelled structures are discussed.

Translated title of the contributionA prediction of the tertiary structure of human phospholipase A2 from synovial fluid and a model of substrate binding
Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number6
Publication statusPublished - Jun 1992

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