The tertiary structure of human Phospholipase A2 (PLA2) from synovial fluid has been predicted by modelling the sequence onto the structure of the homologous snake venom PLA2 structure (Crotalus atrox). A model of substrate binding to the protein has been developed based on the predicted structure of the apoenzyme. These modelled structures are discussed.
|Translated title of the contribution||A prediction of the tertiary structure of human phospholipase A2 from synovial fluid and a model of substrate binding|
|Number of pages||6|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|Publication status||Published - Jun 1992|