A protocol for a novel human ex vivo model of aneurysm

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Aortic aneurysm rupture is a significant cause of premature mortality worldwide. Although animal models exist, some frequently experience aortic rupture and sudden death. An alternative approach is therefore required which would use human material to aid translation. Accordingly, we present an optimised and validated protocol to isolate human umbilical cord arteries and their subsequent deployment within a bioreactor.

Consequently, this reproducible ex vivo human model of aneurysm can be used for pathogenesis studies and accompanying assessment of potential novel therapeutics.
Original languageEnglish
JournalSTAR Protocols
Publication statusAccepted/In press - 9 Aug 2020

Keywords

  • aneurysm
  • model
  • 3Rs

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