TY - JOUR
T1 - A randomised controlled trial investigating efficacy of a novel toothpaste containing calcium silicate and sodium phosphate in dentine hypersensitivity pain reduction compared to a fluoride control toothpaste
T2 - Calcium silicate/phosphate paste for DH
AU - Seong, Joon
AU - Newcombe, Robert G
AU - Matheson, Jane
AU - Weddell, Lynnette
AU - Edwards, Mark
AU - West, Nicola X
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Abstract
Objectives: To compare a calcium silicate and sodium phosphate toothpaste (CSSP) with a fluoride negative control toothpaste for dentine hypersensitivity (DH) pain reduction after 14, 28 and 29 days.
Methods: This was a double blind, parallel study in 247 healthy adults with DH (Schiff score >2, tactile 10-20g) in 2 teeth in different quadrants of the mouth. After acclimatisation, participants were randomised to CSSP or control toothpaste. After measuring baseline sensitivity products were applied twice-daily by toothbrushing, and once daily massaging into the sensitive teeth. Sensitivity was assessed following airblast (Schiff and VAS) and tactile (Yeaple probe) stimuli at baseline, 14 and 28 days, and at 29 days, 12 hours after last product application. Participants completed a quality of life questionnaire at each study visit up to day 28.
Results: After 14, 28 and 29 days the CSSP group had significantly lower Schiff, lower VAS and higher Yeaple probe scores compared to control (VAS at 14 days, p<0.04; all other comparisons, p<0.001). Quality of life scores improved in both groups, but no significant differences between groups were observed.
Conclusions: The CSSP toothpaste was more effective than the fluoride control toothpaste at reducing DH pain with benefit persisting 12 hours following application.
Clinical Significance
This novel calcium silicate and sodium phosphate toothpaste (CSSP) toothpaste is an effective twice-daily treatment when brushed on the teeth for dentine hypersensitivity sufferers compared to brushing with a conventional fluoride paste. Twice-daily brushing provides a sustained effect for long-lasting pain relief from dentine hypersensitivity.
AB - Abstract
Objectives: To compare a calcium silicate and sodium phosphate toothpaste (CSSP) with a fluoride negative control toothpaste for dentine hypersensitivity (DH) pain reduction after 14, 28 and 29 days.
Methods: This was a double blind, parallel study in 247 healthy adults with DH (Schiff score >2, tactile 10-20g) in 2 teeth in different quadrants of the mouth. After acclimatisation, participants were randomised to CSSP or control toothpaste. After measuring baseline sensitivity products were applied twice-daily by toothbrushing, and once daily massaging into the sensitive teeth. Sensitivity was assessed following airblast (Schiff and VAS) and tactile (Yeaple probe) stimuli at baseline, 14 and 28 days, and at 29 days, 12 hours after last product application. Participants completed a quality of life questionnaire at each study visit up to day 28.
Results: After 14, 28 and 29 days the CSSP group had significantly lower Schiff, lower VAS and higher Yeaple probe scores compared to control (VAS at 14 days, p<0.04; all other comparisons, p<0.001). Quality of life scores improved in both groups, but no significant differences between groups were observed.
Conclusions: The CSSP toothpaste was more effective than the fluoride control toothpaste at reducing DH pain with benefit persisting 12 hours following application.
Clinical Significance
This novel calcium silicate and sodium phosphate toothpaste (CSSP) toothpaste is an effective twice-daily treatment when brushed on the teeth for dentine hypersensitivity sufferers compared to brushing with a conventional fluoride paste. Twice-daily brushing provides a sustained effect for long-lasting pain relief from dentine hypersensitivity.
KW - Dentine hypersensitivity
KW - calcium silicate
KW - sodium phosphate
KW - occlusion
KW - toothpaste
KW - pain
U2 - 10.1016/j.jdent.2020.103320
DO - 10.1016/j.jdent.2020.103320
M3 - Article (Academic Journal)
C2 - 32497553
SN - 0300-5712
VL - 98
JO - Journal of Dentistry
JF - Journal of Dentistry
M1 - 103320
ER -