A RAPID ASSAY FOR THE ENANTIOMERIC PURITY OF SECONDARY ALCOHOLS USING 4S,5R-4-METHYL,5-PHENYL-1,3,2-OXAZABOROLIDINE (EPHEDRINEBORANE)

S W LEPPARD, Guy C Lloyd-Jones

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)

Abstract

Reaction of the title compound with a series of racemic and optically enriched secondary alcohols in C7D8 solution at 20-degrees-C leads to rapid formation of the corresponding borate. The N-CH3 protons of the ephedrine moiety, and frequently other resonances, were generally resolved in the H-1 NMR spectrum. permitting an estimation of the enantiomeric purity of the alcohol.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalTetrahedron: Asymmetry
Volume3
Issue number2
Publication statusPublished - 1992

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