A RAPID ASSAY FOR THE ENANTIOMERIC PURITY OF SECONDARY ALCOHOLS USING 4S,5R-4-METHYL,5-PHENYL-1,3,2-OXAZABOROLIDINE (EPHEDRINEBORANE)

Reaction of the title compound with a series of racemic and optically enriched secondary alcohols in C7D8 solution at 20-degrees-C leads to rapid formation of the corresponding borate. The N-CH3 protons of the ephedrine moiety, and frequently other resonances, were generally resolved in the H-1 NMR spectrum. permitting an estimation of the enantiomeric purity of the alcohol.