A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
261 Downloads (Pure)

Abstract

Genome-wide association studies have revealed an association between several loci in the nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 and daily cigarette consumption. Recent studies have sought to refine this phenotype, and have shown that a locus within this cluster, marked primarily by rs1051730 and rs16969968, is also associated with levels of cotinine, the primary metabolite of nicotine. This association remains after adjustment for self-reported smoking, which suggests that even amongst people who smoke the same number of cigarettes there is still genetically-influenced variation in nicotine consumption. This is likely to be due to differences in smoking topography, that is, how a cigarette is smoked (e.g., volume of smoke inhaled per puff, number of puffs taken per cigarette). The aim of this study is to determine potential mediation of the relationship between the rs1051730 locus and cotinine levels by smoking topography.
Original languageEnglish
Article number13
Number of pages5
JournalBMC Medical Genetics
Volume15
DOIs
Publication statusPublished - 22 Jan 2014

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

Fingerprint Dive into the research topics of 'A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol'. Together they form a unique fingerprint.

  • Projects

    MRC UoB UNITE Unit - Programme 1

    Davey Smith, G.

    1/06/1331/03/18

    Project: Research

    MRC UoB UNITE Unit - programme 3

    Timpson, N. J. & Timpson, N. J.

    1/06/1331/03/18

    Project: Research

    MRC UoB UNITE Unit - Programme 6

    Munafo, M. R. & Munafo, M. R.

    1/06/1331/03/18

    Project: Research

    Cite this