A robust first-pass protocol for the heck-mizoroki reaction

Paul M. Murray*, John F. Bower, David K. Cox, Ewan K. Galbraith, Jeremy S. Parker, Joseph B. Sweeney

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

34 Citations (Scopus)

Abstract

The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalOrganic Process Research & Development
Volume17
Issue number3
DOIs
Publication statusPublished - 15 Mar 2013

Fingerprint Dive into the research topics of 'A robust first-pass protocol for the heck-mizoroki reaction'. Together they form a unique fingerprint.

Cite this