A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition

David Maldonado-Perez, Ellen Golightly, Fiona C. Denison, Henry N. Jabbour, Jane E. Norman

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The purpose of this study was to investigate the role of lipoxin A(4), an anti-inflammatory and proresolution modulator, during human parturition. We measured serum levels of lipoxin A(4) and myometrial protein release using ELISA, quantified lipoxin receptor (FPR2/ALX) mRNA expression using qRT-PCR, and localized protein expression using immuno-histochemstry in myometrial biopsies from pregnant women. In addition, we compared the effects of lipoxin A(4) (100 nM) with vehicle on basal and LPS-stimulated expression of proinflammatory cytokines from samples of myometrium from pregnant women. Mean +/- SE circulating level of lipoxin A(4) was 5.89 +/- 0.63 nM at 24-wk gestation, with a further modest increase during pregnancy (P0.05). Levels of lipoxin A(4) in nonpregnant women were 0.48 +/- 0.04 nM, significantly lower than in pregnant women (P
Original languageEnglish
Pages (from-to)569-575
Number of pages7
JournalFASEB Journal
Volume25
Issue number2
DOIs
Publication statusPublished - 2011

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Keywords

  • labor lipoxin receptor myometrium inflammation proinflammatory cytokines

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