A role of WT1 in cell division and genomic stability

Jayasha Shandilya, Stefan G E Roberts

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

Wilms' tumor-1 protein (WT1) is a transcription factor that can either activate or repress genes to regulate cell growth, apoptosis and differentiation. WT1 can act as either a tumor suppressor or an oncogene. The cellular functions of WT1 are predominantly regulated by its various interacting partners. Recently we have found that WT1 can regulate the fidelity of chromosome segregation through its interaction with the spindle assembly checkpoint protein, Mitotic arrest deficient-2 (MAD2). WT1 delays anaphase entry by inhibiting the ubiquitination activity of the Anaphase promoting complex/cyclosome (APC/C). Our findings have revealed an important role of WT1 in the regulation of mitotic checkpoint and genomic stability.

Original languageEnglish
Pages (from-to)1358-64
Number of pages7
JournalCell Cycle
Volume14
Issue number9
DOIs
Publication statusPublished - 2015

Keywords

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle Checkpoints
  • Cell Cycle Proteins
  • Chromosome Segregation
  • Genomic Instability
  • Humans
  • Mad2 Proteins
  • Mitosis
  • Signal Transduction
  • Tumor Suppressor Protein p53
  • WT1 Proteins

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