A short history of heme dioxygenases: rise, fall and rise again

Emma L. Raven*

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)peer-review

26 Citations (Scopus)
212 Downloads (Pure)

Abstract

It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O2-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.
Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalJournal of Biological Inorganic Chemistry
Volume22
Issue number2-3
Early online date1 Dec 2016
DOIs
Publication statusPublished - 1 Apr 2017

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