TY - JOUR
T1 - A short history of heme dioxygenases
T2 - rise, fall and rise again
AU - Raven, Emma L.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O2-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.
AB - It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O2-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.
UR - http://www.scopus.com/inward/record.url?scp=85001104546&partnerID=8YFLogxK
U2 - 10.1007/s00775-016-1412-5
DO - 10.1007/s00775-016-1412-5
M3 - Letter (Academic Journal)
C2 - 27909919
AN - SCOPUS:85001104546
SN - 0949-8257
VL - 22
SP - 175
EP - 183
JO - Journal of Biological Inorganic Chemistry
JF - Journal of Biological Inorganic Chemistry
IS - 2-3
ER -