A short history of heme dioxygenases: rise, fall and rise again

Emma L. Raven

doi:10.1007/s00775-016-1412-5

A short history of heme dioxygenases: rise, fall and rise again

Emma L. Raven^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

54 Citations (Scopus)

368 Downloads (Pure)

Abstract

It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O₂-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.

Original language	English
Pages (from-to)	175-183
Number of pages	9
Journal	Journal of Biological Inorganic Chemistry
Volume	22
Issue number	2-3
Early online date	1 Dec 2016
DOIs	https://doi.org/10.1007/s00775-016-1412-5
Publication status	Published - 1 Apr 2017

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Inorganic & Materials

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abstract = "It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O2-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.",

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AB - It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O2-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.

UR - https://www.scopus.com/pages/publications/85001104546

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DO - 10.1007/s00775-016-1412-5

M3 - Letter (Academic Journal)

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AN - SCOPUS:85001104546

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SP - 175

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JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

IS - 2-3

ER -

A short history of heme dioxygenases: rise, fall and rise again

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