A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times: Decision to swim

Stella Koutsikou, Robert Merrison-Hort, Edgar Buhl, Andrea Ferrario, Wen-Chang Li, Roman Borisyuk, Stephen R Soffe, Alan Roberts

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)
162 Downloads (Pure)

Abstract

Many motor responses to sensory input, like locomotion or eye movements, are much slower than reflexes. Can simpler animals provide fundamental answers about the cellular mechanisms for motor decisions? Can we observe the ‘accumulation’ of excitation to threshold proposed to underlie decision making elsewhere? We explore how somatosensory touch stimulation leads to the decision to swim in hatchling Xenopus tadpoles. Delays measured to swimming in behaving and immobilized tadpoles are long and variable. Activity in their extensively studied sensory and sensory pathway neurons is too short-lived to explain these response delays. Instead, whole-cell recordings from the hindbrain reticulospinal neurons that drive swimming show these receive prolonged, variable synaptic excitation lasting for nearly a second following a brief stimulus. They fire and initiate swimming when this excitation reaches threshold. Analysis of the summation of excitation requires us to propose extended firing in currently undefined presynaptic hindbrain neurons. Simple models show that a small excitatory recurrent-network inserted in the sensory pathway can mimic this process. We suggest that such a network may generate slow, variable summation of excitation to threshold. This excitation provides a simple memory of the sensory stimulus. It allows temporal and spatial integration of sensory inputs and explains the long, variable delays to swimming. The process resembles the ‘accumulation’ of excitation proposed for cortical circuits in mammals. We conclude that fundamental elements of sensory memory and decision making are present in the brainstem at a surprisingly early stage in development.
Original languageEnglish
Number of pages15
JournalJournal of Physiology
Early online date19 Sep 2018
DOIs
Publication statusE-pub ahead of print - 19 Sep 2018

Keywords

  • Decision-making
  • Xenopus laevis
  • Reticulospinal neurons,
  • Locomotion
  • Somatosensory

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