A single population of cells in the male rat anterior pituitary responds mitotically to both gonadectomy and adrenalectomy

LA Nolan; A Levy

A single population of cells in the male rat anterior pituitary responds mitotically to both gonadectomy and adrenalectomy

LA Nolan, A Levy

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Abstract

The male rat anterior pituitary responds highly reproducibly to specific hormonal stimuli in terms of the extent and timing of mitotic and apoptotic (ie. trophic) activity, as well as changes in hormone secretion. Unlike the latter, which is easily attributable to a specific cellular subpopulation, the nature of the cells that respond trophically, and therefore the extent of the contribution of hormonally identifiable cells to the mitotic response is much harder to define. The mitotic response to bilateral adrenalectomy and bilateral gonadectomy are very similar. Each is characterized by a gradual 2- to 3-fold increase in mitotic activity to a peak 3 to 4 days post-surgery followed by a gradual return to baseline levels over the subsequent 10 days. As far as apoptotic responsiveness, the short lived burst of apoptotic activity induced by dexamethasone in cells formed within the previous 10-14 days is enhanced in amplitude 2- to 3-fold not only by prior adrenalectomy, but also, somewhat surprisingly, by gonadectomy. We have shown in the present study that the amplitude of the mitotic response when surgical adrenalectomy and gonadectomy are combined, is no bigger than that seen after adrenalectomy or gonadectomy alone. Similarly, combining gonadectomy and adrenalectomy does not enhance the size of the dexamethasone-sensitive apoptotically responsive cell population generated by recent mitotic activity. Unless there is a substantial cross-axis inhibitory effect on mitotic activity, these data strongly suggest that the same population of cells respond mitotically to both adrenalectomy and gonadectomy. This finding supports the concept of a progenitor cell population that responds to several different hormonal stimuli, and weakens the prevailing concept that hormonally identifiable cells with specific mitotic and apoptotic response profiles contribute significantly to trophic activity in the pituitary.

Translated title of the contribution	A single population of cells in the male rat anterior pituitary responds mitotically to both gonadectomy and adrenalectomy
Original language	English
Title of host publication	Association of Physicians of Great Britain and Ireland
Pages	P12
Publication status	Published - 2007

Bibliographical note

Name and Venue of Event: Association of Physicians annual meeting
Conference Proceedings/Title of Journal: Quarterly Journal of Medicine
Conference Organiser: Association of Physicians

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title = "A single population of cells in the male rat anterior pituitary responds mitotically to both gonadectomy and adrenalectomy",

abstract = "The male rat anterior pituitary responds highly reproducibly to specific hormonal stimuli in terms of the extent and timing of mitotic and apoptotic (ie. trophic) activity, as well as changes in hormone secretion. Unlike the latter, which is easily attributable to a specific cellular subpopulation, the nature of the cells that respond trophically, and therefore the extent of the contribution of hormonally identifiable cells to the mitotic response is much harder to define. The mitotic response to bilateral adrenalectomy and bilateral gonadectomy are very similar. Each is characterized by a gradual 2- to 3-fold increase in mitotic activity to a peak 3 to 4 days post-surgery followed by a gradual return to baseline levels over the subsequent 10 days. As far as apoptotic responsiveness, the short lived burst of apoptotic activity induced by dexamethasone in cells formed within the previous 10-14 days is enhanced in amplitude 2- to 3-fold not only by prior adrenalectomy, but also, somewhat surprisingly, by gonadectomy. We have shown in the present study that the amplitude of the mitotic response when surgical adrenalectomy and gonadectomy are combined, is no bigger than that seen after adrenalectomy or gonadectomy alone. Similarly, combining gonadectomy and adrenalectomy does not enhance the size of the dexamethasone-sensitive apoptotically responsive cell population generated by recent mitotic activity. Unless there is a substantial cross-axis inhibitory effect on mitotic activity, these data strongly suggest that the same population of cells respond mitotically to both adrenalectomy and gonadectomy. This finding supports the concept of a progenitor cell population that responds to several different hormonal stimuli, and weakens the prevailing concept that hormonally identifiable cells with specific mitotic and apoptotic response profiles contribute significantly to trophic activity in the pituitary.",

author = "LA Nolan and A Levy",

note = "Name and Venue of Event: Association of Physicians annual meeting Conference Proceedings/Title of Journal: Quarterly Journal of Medicine Conference Organiser: Association of Physicians",

year = "2007",

language = "English",

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T1 - A single population of cells in the male rat anterior pituitary responds mitotically to both gonadectomy and adrenalectomy

AU - Nolan, LA

AU - Levy, A

N1 - Name and Venue of Event: Association of Physicians annual meeting Conference Proceedings/Title of Journal: Quarterly Journal of Medicine Conference Organiser: Association of Physicians

PY - 2007

Y1 - 2007

N2 - The male rat anterior pituitary responds highly reproducibly to specific hormonal stimuli in terms of the extent and timing of mitotic and apoptotic (ie. trophic) activity, as well as changes in hormone secretion. Unlike the latter, which is easily attributable to a specific cellular subpopulation, the nature of the cells that respond trophically, and therefore the extent of the contribution of hormonally identifiable cells to the mitotic response is much harder to define. The mitotic response to bilateral adrenalectomy and bilateral gonadectomy are very similar. Each is characterized by a gradual 2- to 3-fold increase in mitotic activity to a peak 3 to 4 days post-surgery followed by a gradual return to baseline levels over the subsequent 10 days. As far as apoptotic responsiveness, the short lived burst of apoptotic activity induced by dexamethasone in cells formed within the previous 10-14 days is enhanced in amplitude 2- to 3-fold not only by prior adrenalectomy, but also, somewhat surprisingly, by gonadectomy. We have shown in the present study that the amplitude of the mitotic response when surgical adrenalectomy and gonadectomy are combined, is no bigger than that seen after adrenalectomy or gonadectomy alone. Similarly, combining gonadectomy and adrenalectomy does not enhance the size of the dexamethasone-sensitive apoptotically responsive cell population generated by recent mitotic activity. Unless there is a substantial cross-axis inhibitory effect on mitotic activity, these data strongly suggest that the same population of cells respond mitotically to both adrenalectomy and gonadectomy. This finding supports the concept of a progenitor cell population that responds to several different hormonal stimuli, and weakens the prevailing concept that hormonally identifiable cells with specific mitotic and apoptotic response profiles contribute significantly to trophic activity in the pituitary.

AB - The male rat anterior pituitary responds highly reproducibly to specific hormonal stimuli in terms of the extent and timing of mitotic and apoptotic (ie. trophic) activity, as well as changes in hormone secretion. Unlike the latter, which is easily attributable to a specific cellular subpopulation, the nature of the cells that respond trophically, and therefore the extent of the contribution of hormonally identifiable cells to the mitotic response is much harder to define. The mitotic response to bilateral adrenalectomy and bilateral gonadectomy are very similar. Each is characterized by a gradual 2- to 3-fold increase in mitotic activity to a peak 3 to 4 days post-surgery followed by a gradual return to baseline levels over the subsequent 10 days. As far as apoptotic responsiveness, the short lived burst of apoptotic activity induced by dexamethasone in cells formed within the previous 10-14 days is enhanced in amplitude 2- to 3-fold not only by prior adrenalectomy, but also, somewhat surprisingly, by gonadectomy. We have shown in the present study that the amplitude of the mitotic response when surgical adrenalectomy and gonadectomy are combined, is no bigger than that seen after adrenalectomy or gonadectomy alone. Similarly, combining gonadectomy and adrenalectomy does not enhance the size of the dexamethasone-sensitive apoptotically responsive cell population generated by recent mitotic activity. Unless there is a substantial cross-axis inhibitory effect on mitotic activity, these data strongly suggest that the same population of cells respond mitotically to both adrenalectomy and gonadectomy. This finding supports the concept of a progenitor cell population that responds to several different hormonal stimuli, and weakens the prevailing concept that hormonally identifiable cells with specific mitotic and apoptotic response profiles contribute significantly to trophic activity in the pituitary.

M3 - Conference Contribution (Conference Proceeding)

SP - P12

BT - Association of Physicians of Great Britain and Ireland

ER -