A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

Luke Elliott; Malcolm B. Berry; Bashir Harji; David Klauber; John Leonard; Kevin Booker-Milburn

doi:10.1021/acs.oprd.6b00277

A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

Luke Elliott, Malcolm B. Berry, Bashir Harji, David Klauber, John Leonard, Kevin Booker-Milburn

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

113 Citations (Scopus)

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Abstract

The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

Original language	English
Pages (from-to)	1806-1811
Number of pages	6
Journal	Organic Process Research & Development
Volume	20
Issue number	10
Early online date	15 Sept 2016
DOIs	https://doi.org/10.1021/acs.oprd.6b00277
Publication status	Published - 21 Oct 2016

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10.1021/acs.oprd.6b00277

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This is the accepted author manuscript (AAM). The final published version (version of record) is available online via American Chemical Society at http://doi.org/10.1021/acs.oprd.6b00277. Please refer to any applicable terms of use of the publisher.
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Factory in a Fumehood.
Booker-Milburn, K. I. (Principal Investigator)
1/10/13 → 1/03/17
Project: Research

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abstract = "The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.",

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AU - Berry, Malcolm B.

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AU - Klauber, David

AU - Leonard, John

AU - Booker-Milburn, Kevin

PY - 2016/10/21

Y1 - 2016/10/21

N2 - The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

AB - The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

U2 - 10.1021/acs.oprd.6b00277

DO - 10.1021/acs.oprd.6b00277

M3 - Article (Academic Journal)

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EP - 1811

JO - Organic Process Research & Development

JF - Organic Process Research & Development

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ER -

A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

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Factory in a Fumehood.

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