A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

Luke Elliott; Malcolm B. Berry; Bashir Harji; David Klauber; John Leonard; Kevin Booker-Milburn

doi:10.1021/acs.oprd.6b00277

A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

Luke Elliott, Malcolm B. Berry, Bashir Harji, David Klauber, John Leonard, Kevin Booker-Milburn

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

127 Citations (Scopus)

558 Downloads (Pure)

Abstract

The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

Original language	English
Pages (from-to)	1806-1811
Number of pages	6
Journal	Organic Process Research & Development
Volume	20
Issue number	10
Early online date	15 Sept 2016
DOIs	https://doi.org/10.1021/acs.oprd.6b00277
Publication status	Published - 21 Oct 2016

Access to Document

10.1021/acs.oprd.6b00277

Firefly_OPRD_revised_no_highlights
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via American Chemical Society at http://doi.org/10.1021/acs.oprd.6b00277. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 847 KB

Handle.net

Persistent link

Factory in a Fumehood.
Booker-Milburn, K. I. (Principal Investigator)
1/10/13 → 1/03/17
Project: Research

Cite this

@article{f831bcc282b84ebcb96371f44efd2d81,

title = "A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale",

abstract = "The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30\% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.",

author = "Luke Elliott and Berry, \{Malcolm B.\} and Bashir Harji and David Klauber and John Leonard and Kevin Booker-Milburn",

year = "2016",

month = oct,

day = "21",

doi = "10.1021/acs.oprd.6b00277",

language = "English",

volume = "20",

pages = "1806--1811",

journal = "Organic Process Research \& Development",

issn = "1083-6160",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

AU - Elliott, Luke

AU - Berry, Malcolm B.

AU - Harji, Bashir

AU - Klauber, David

AU - Leonard, John

AU - Booker-Milburn, Kevin

PY - 2016/10/21

Y1 - 2016/10/21

N2 - The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

AB - The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

U2 - 10.1021/acs.oprd.6b00277

DO - 10.1021/acs.oprd.6b00277

M3 - Article (Academic Journal)

SN - 1083-6160

VL - 20

SP - 1806

EP - 1811

JO - Organic Process Research & Development

JF - Organic Process Research & Development

IS - 10

ER -

A Small Footprint, High Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

Abstract

Access to Document

Handle.net

Fingerprint

Projects

Factory in a Fumehood.

Cite this