A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols

Alastair J J Lennox*, Bert C Rowett, David M Heard, Stephen G Sweeting

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

A general haloform coupling reaction for the synthesis of esters from methyl ketones is reported using one equivalent of alcohol. Detailed kinetic modelling studies demonstrate that the key intermediates are formed under equilibrium, which led to the development of conditions that are amenable to secondary alcohols.
Original languageEnglish
Article numbere202400570
JournalAngewandte Chemie International Edition
Volume63
Issue number21
DOIs
Publication statusPublished - 24 Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

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