A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols

Alastair J J Lennox; Bert C Rowett; David M Heard; Stephen G Sweeting

doi:10.1002/anie.202400570

A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols

Alastair J J Lennox^*, Bert C Rowett, David M Heard, Stephen G Sweeting

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

Abstract

A general haloform coupling reaction for the synthesis of esters from methyl ketones is reported using one equivalent of alcohol. Detailed kinetic modelling studies demonstrate that the key intermediates are formed under equilibrium, which led to the development of conditions that are amenable to secondary alcohols.

Original language	English
Article number	e202400570
Number of pages	7
Journal	Angewandte Chemie International Edition
Volume	63
Issue number	21
Early online date	27 Mar 2024
DOIs	https://doi.org/10.1002/anie.202400570
Publication status	Published - 21 May 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Access to Document

10.1002/anie.202400570Licence: CC BY

Handle.net

Persistent link

Cite this

@article{17147c54722443769f72494c76d2d917,

title = "A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols",

abstract = "A general haloform coupling reaction for the synthesis of esters from methyl ketones is reported using one equivalent of alcohol. Detailed kinetic modelling studies demonstrate that the key intermediates are formed under equilibrium, which led to the development of conditions that are amenable to secondary alcohols. ",

author = "Lennox, {Alastair J J} and Rowett, {Bert C} and Heard, {David M} and Sweeting, {Stephen G}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.",

year = "2024",

month = may,

day = "21",

doi = "10.1002/anie.202400570",

language = "English",

volume = "63",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "Wiley-VCH Verlag",

number = "21",

}

TY - JOUR

T1 - A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols

AU - Lennox, Alastair J J

AU - Rowett, Bert C

AU - Heard, David M

AU - Sweeting, Stephen G

PY - 2024/5/21

Y1 - 2024/5/21

N2 - A general haloform coupling reaction for the synthesis of esters from methyl ketones is reported using one equivalent of alcohol. Detailed kinetic modelling studies demonstrate that the key intermediates are formed under equilibrium, which led to the development of conditions that are amenable to secondary alcohols.

AB - A general haloform coupling reaction for the synthesis of esters from methyl ketones is reported using one equivalent of alcohol. Detailed kinetic modelling studies demonstrate that the key intermediates are formed under equilibrium, which led to the development of conditions that are amenable to secondary alcohols.

U2 - 10.1002/anie.202400570

DO - 10.1002/anie.202400570

M3 - Article (Academic Journal)

C2 - 38533790

SN - 1433-7851

VL - 63

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 21

M1 - e202400570

ER -

A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols

Abstract

Bibliographical note

Access to Document

Handle.net

Fingerprint

Cite this