A study of wrist-worn activity measurement as a potential real-world biomarker for late-life depression

Roisin McNaney, John O'Brien, Peter Gallagher, Daniel Stow, Nils Hammerla, Thomas Ploetz, M Firbank, Cassim Ladha, Karim Ladha, Dan Jackson, Nicol Ferrier, Patrick Olivier

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Background Late-life depression (LLD) is associated with a decline in physical activity. Typically this is assessed by self-report questionnaires and, more recently, with actigraphy. We sought to explore the utility of a bespoke activity monitor to characterize activity profiles in LLD more precisely. Method The activity monitor was worn for 7 days by 29 adults with LLD and 30 healthy controls. Subjects underwent neuropsychological assessment and quality of life (QoL) (36-item Short-Form Health Survey) and activities of daily living (ADL) scales (Instrumental Activities of Daily Living Scale) were administered. Results Physical activity was significantly reduced in LLD compared with controls (t = 3.63, p < 0.001), primarily in the morning. LLD subjects showed slower fine motor movements (t = 3.49, p < 0.001). In …
Original languageEnglish
Pages (from-to)93
Number of pages102
JournalPsychological Medicine
Volume47
Issue number1
Publication statusPublished - 2017

Structured keywords

  • Digital Health

Keywords

  • Digital Health

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