A systematic genomewide linkage study in 353 sib pairs with schizophrenia

Nigel Melville Williams, Nadine Norton, Hywel John Williams, B. Ekholm, Marian Lindsay Hamshere, Y. Lindblom, K. V. Chowdari, Alastair George Cardno, Stanley Zammit, Lisa Anne Jones, Kieran Christopher Murphy, Robert David Sanders, Geraldine MaryTeresa McCarthy, Marion Yvonne Gray, G. Jones, Peter Alan Holmans, V. Nimgaonkar, R. Adolfson, U. Osby, L. TereniusG. Sedvall, Michael Conlon O'Donovan, Michael John Owen

Research output: Contribution to journalArticle (Academic Journal)peer-review

105 Citations (Scopus)

Abstract

We undertook a genomewide linkage study in a total of 353 affected sib pairs (ASPs) with schizophrenia. Our sample consisted of 179 ASPs from the United Kingdom, 134 from Sweden, and 40 from the United States. We typed 372 microsatellite markers at 10-cM intervals. Our strongest finding was a LOD score of 3.87 on chromosome 10q25.3-q26.3, with positive results being contributed by all three samples and a LOD-1 interval of 15 cM. This finding achieved genomewide significance (P
Original languageEnglish
Pages (from-to)1355-1367
Number of pages13
JournalAmerican Journal of Human Genetics
Volume73
Issue number6
DOIs
Publication statusPublished - 1 Dec 2003

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