A systematic review of dietary, nutritional, and physical activity interventions for the prevention of prostate cancer progression and mortality

Lucy E. Hackshaw-McGeagh*, Rachel E. Perry, Verity A. Leach, Sara Qandil, Mona Jeffreys, Richard M. Martin, J. Athene Lane

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)

47 Citations (Scopus)
395 Downloads (Pure)

Abstract

Purpose: Given the long-term, although potentially fatal, nature of prostate cancer, there is increasing observational evidence for the reduction in disease progression and mortality through changes in lifestyle factors. Methods: We systematically reviewed dietary, nutritional, and physical activity randomized interventions aimed at modifying prostate cancer progression and disease-specific mortality, including a detailed assessment of risk of bias and methodological quality. Results: Forty-four randomized controlled trials of lifestyle interventions, with prostate cancer progression or mortality outcomes, were identified. Substantial heterogeneity of the data prevented a meta-analysis. The included trials involved 3,418 prostate cancer patients, median 64 men per trial, from 13 countries. A trial of a nutritional supplement of pomegranate seed, green tea, broccoli, and turmeric; a trial comparing flaxseed, low-fat diet, flaxseed, and low-fat diet versus usual diet; and a trial supplementing soy, lycopene, selenium, and coenzyme Q10, all demonstrated beneficial effects. These trials were also assessed as having low risk of bias and high methodological quality (as were seven other trials with no evidence of benefit). The remaining trials were either underpowered, at high or unclear risk of bias, inadequately reported, of short duration or measured surrogate outcomes of unproven relationship to mortality or disease progression, which precluded any benefits reported being reliable. Conclusion: Large, well-designed randomized trials with clinical endpoints are recommended for lifestyle modification interventions.

Original languageEnglish
Pages (from-to)1521-1550
Number of pages30
JournalCancer Causes and Control
Volume26
Issue number11
Early online date9 Sep 2015
DOIs
Publication statusPublished - 1 Nov 2015

Structured keywords

  • ICEP
  • Centre for Surgical Research

Keywords

  • Diet
  • Nutrition
  • Physical activity
  • Prostate cancer
  • Randomized controlled trials
  • Systematic review

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