A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2

Katharine J Looker, G P Garnett

Research output: Contribution to journalArticle (Academic Journal)peer-review

95 Citations (Scopus)

Abstract

OBJECTIVES: To explore epidemiological evidence about the interaction of herpes simplex virus (HSV) 1 and HSV-2 infections.

METHODS: A systematic review was undertaken of published epidemiological studies describing the pattern of HSV-1 or HSV-2 by age, and the coincidence of the two viral infections.

RESULTS: In cross sectional studies the unadjusted odds of HSV-2 are greater in those with HSV-1 infection in study populations categorised as "low risk" (p = 0.06) and across European populations (p = 0.001). This was not evident in "high risk" populations or in the United States. This increased risk of HSV-2 in those with HSV-1 infection does not agree with the results of prospective studies where there is a non-significant trend towards a lower risk of HSV-2 infection associated with previous HSV-1 infection.

CONCLUSIONS: "Low risk" and European populations have a relatively low HSV-2 seroprevalence and infection is more concentrated in those with characteristics putting them at high risk for both HSV-1 and HSV-2. This confounding could mask any protective effect of HSV-1, which is hinted at, but not demonstrated, in prospective and adjusted studies.

Original languageEnglish
Pages (from-to)103-7
Number of pages5
JournalSexually Transmitted Infections
Volume81
Issue number2
DOIs
Publication statusPublished - Apr 2005

Keywords

  • Herpes Simplex
  • Herpesvirus 1, Human
  • Herpesvirus 2, Human
  • Humans
  • Odds Ratio
  • Prevalence

Fingerprint Dive into the research topics of 'A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2'. Together they form a unique fingerprint.

Cite this