A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia

Cerys Oliver, Haoxuan Li, Bijetri Biswas, David A Woodstoke, Jonathan Blackman, Anneka F Butters, Cheney Drew, Victoria G Gabb, Samantha A Harding, Camilla Hoyos, Adrian H Kendrick, Sarah Rudd, Nicholas L Turner, E J Coulthard*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

2 Citations (Scopus)
68 Downloads (Pure)

Abstract

Obstructive sleep apnoea (OSA) is highly prevalent in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The gold standard treatment for OSA is continuous positive airway pressure (CPAP). Long-term, well-powered efficacy trials are required to understand whether CPAP could slow cognitive decline in MCI/AD, but its tolerability in this group remains uncertain. The present review investigates CPAP adherence among individuals with OSA and MCI/AD. Electronic searches were performed on 8 databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Six independent studies and four secondary analyses included 278 unique participants (mean age = 72.1 years). In five of the retained studies, around half of participants (45% N = 85 MCI, 56% N = 22 AD) were adherent to CPAP, where 4 hours use per night was considered adherent. Three of the retained studies also reported average CPAP use to range between 3.2 – 6.3 hours/night. CPAP adherence in MCI and AD patients is low, albeit similar to the general elderly population. The question remains as to whether this will be adequate for long-term protection of brain heath.
Original languageEnglish
Article number101869
Pages (from-to)1-25
JournalSleep Medicine Reviews
Volume73
Early online date24 Oct 2023
DOIs
Publication statusE-pub ahead of print - 24 Oct 2023

Bibliographical note

Funding Information:
This research was supported by Above and Beyond Charity. Thanks to Southmead Library, North Bristol NHS Trust.

Publisher Copyright:
© 2023 The Authors

Keywords

  • Obstructive Sleep Apnoea
  • Sleep
  • MCI
  • Dementia
  • Systematic Review

Fingerprint

Dive into the research topics of 'A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia'. Together they form a unique fingerprint.

Cite this