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A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Research output: Contribution to journalArticle

  • JT Handa
  • C Bowes Rickman
  • Andrew Dick
  • M B Gorin
  • J W Miller
  • C A Toth
  • M Ueffing
  • M Zarbin
  • L A Farrer
Original languageEnglish
Article number3347
Number of pages11
JournalNature Communications
Volume10
Issue number1
DOIs
DateAccepted/In press - 3 Jul 2019
DatePublished (current) - 26 Jul 2019

Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Springer Nature at https://doi.org/10.1038/s41467-019-11262-1 . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

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