Abnormal cardiac enzymes in systemic sclerosis: a report of four patients and review of the literature

B Vasta, V Flower, C Bucciarelli-Ducci, S Brown, E Korendowych, N J McHugh, J D Pauling

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)


Cardiac involvement in systemic sclerosis (SSc) is heterogeneous and can include primary involvement of the myocardium, pericardium and coronary arteries or be secondary to cardiac complications of pulmonary and renal disease. Primary cardiac involvement in SSc is uncommon but can result in ventricular dysfunction, organ failure, arrhythmias and death. It can remain clinically silent and the prevalence is likely to be under-reported. We report four cases of SSc associated with a raised serum troponin T (TnT), in a proportion of whom cardiac MRI myocardial abnormalities were detected. These cases highlight the heterogeneity of cardiac involvement in SSc, the role of cardiac MRI and promising biochemical responses to immunosuppression. Cardiac biomarkers such as TnT may be useful screening tools to identify subclinical cardiac disease and assess response to therapeutic intervention.

Original languageEnglish
Pages (from-to)435-8
Number of pages4
JournalClinical Rheumatology
Issue number3
Publication statusPublished - Mar 2014


  • Adult
  • Aged
  • Female
  • Heart
  • Heart Diseases
  • Humans
  • Male
  • Middle Aged
  • Myocardium
  • Scleroderma, Systemic
  • Troponin T
  • Case Reports
  • Journal Article
  • Review

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