Abnormal liver function in children with metabolic syndrome from a UK-based obesity clinic

C Wei, A Ford, LP Hunt, E Crowne, JPH Shield

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Abstract

Aim To examine transaminitis in obese children, its association with glucose metabolism and the metabolic syndrome and the response to weight loss through lifestyle modification. Methods 216 children (90 male), aged 2.9-17.6 (median 12.4 years) with median body mass index (BMI) SD score (SDS) of 3.36 (range 1.92-6.22) attending a hospital obesity clinic in Bristol (UK) underwent an oral glucose tolerance test (OGTT) with fasting lipid and liver profile. Auxological measures included weight, height, waist circumference, percentage body fat. Parental history of type 2 diabetes (T2DM) was recorded. The 2007 International Diabetes Federation definition of metabolic syndrome was used. 90 children undergoing a trial of lifestyle modification to improve weight were re-assessed at 12 months. Results 34/216 (16%) children had raised alanine aminotransferase (ALT) (>40 IU/l) with greater prevalence in boys (23% vs 10%, p=0.01) and in those with a parental history of T2DM (30% vs 13.2% p=0.019). Patients with transaminitis were more likely to fulfil the criteria for metabolic syndrome (p
Translated title of the contributionAbnormal liver function in children with metabolic syndrome from a UK-based obesity clinic
Original languageEnglish
Pages (from-to)1003 - 1007
Number of pages4
JournalArchives of Disease in Childhood
Volume96(11)
DOIs
Publication statusPublished - Nov 2010

Fingerprint Dive into the research topics of 'Abnormal liver function in children with metabolic syndrome from a UK-based obesity clinic'. Together they form a unique fingerprint.

Cite this