Absence of platelet phenotype in mice lacking the motor protein myosin Va

Matthew T Harper; Marion T J van den Bosch; Ingeborg Hers; Alastair W Poole

doi:10.1371/journal.pone.0053239

Absence of platelet phenotype in mice lacking the motor protein myosin Va

Matthew T Harper, Marion T J van den Bosch, Ingeborg Hers, Alastair W Poole

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both characterised by pigment dilution and neurological defects as a result of impaired vesicle transport in melanocytes and neuroendocrine cells. The role of myosin Va in platelets is currently unknown. Rab27 has been shown to be associated with myosin Va cargo vesicles and is known to be important in platelet dense granule biogenesis and secretion, a crucial event in thrombus formation. Therefore, we hypothesised that myosin Va may regulate granule secretion or formation in platelets.

Original language	English
Pages (from-to)	e53239
Journal	PLOS ONE
Volume	8
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0053239
Publication status	Published - 2013

Keywords

Phenotype
Secretory Vesicles
Animals
Blood Platelets
Platelet Glycoprotein GPIIb-IIIa Complex
Myosin Type V
Myosin Heavy Chains
Mice
Cell Shape
Male
Female
Calcium Signaling

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title = "Absence of platelet phenotype in mice lacking the motor protein myosin Va",

abstract = "The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both characterised by pigment dilution and neurological defects as a result of impaired vesicle transport in melanocytes and neuroendocrine cells. The role of myosin Va in platelets is currently unknown. Rab27 has been shown to be associated with myosin Va cargo vesicles and is known to be important in platelet dense granule biogenesis and secretion, a crucial event in thrombus formation. Therefore, we hypothesised that myosin Va may regulate granule secretion or formation in platelets.",

keywords = "Phenotype, Secretory Vesicles, Animals, Blood Platelets, Platelet Glycoprotein GPIIb-IIIa Complex, Myosin Type V, Myosin Heavy Chains, Mice, Cell Shape, Male, Female, Calcium Signaling",

author = "Harper, \{Matthew T\} and \{van den Bosch\}, \{Marion T J\} and Ingeborg Hers and Poole, \{Alastair W\}",

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T1 - Absence of platelet phenotype in mice lacking the motor protein myosin Va

AU - Harper, Matthew T

AU - van den Bosch, Marion T J

AU - Hers, Ingeborg

AU - Poole, Alastair W

PY - 2013

Y1 - 2013

N2 - The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both characterised by pigment dilution and neurological defects as a result of impaired vesicle transport in melanocytes and neuroendocrine cells. The role of myosin Va in platelets is currently unknown. Rab27 has been shown to be associated with myosin Va cargo vesicles and is known to be important in platelet dense granule biogenesis and secretion, a crucial event in thrombus formation. Therefore, we hypothesised that myosin Va may regulate granule secretion or formation in platelets.

AB - The motor protein myosin Va plays an important role in the trafficking of intracellular vesicles. Mutation of the Myo5a gene causes Griscelli syndrome type 1 in humans and the dilute phenotype in mice, which are both characterised by pigment dilution and neurological defects as a result of impaired vesicle transport in melanocytes and neuroendocrine cells. The role of myosin Va in platelets is currently unknown. Rab27 has been shown to be associated with myosin Va cargo vesicles and is known to be important in platelet dense granule biogenesis and secretion, a crucial event in thrombus formation. Therefore, we hypothesised that myosin Va may regulate granule secretion or formation in platelets.

KW - Phenotype

KW - Secretory Vesicles

KW - Animals

KW - Blood Platelets

KW - Platelet Glycoprotein GPIIb-IIIa Complex

KW - Myosin Type V

KW - Myosin Heavy Chains

KW - Mice

KW - Cell Shape

KW - Male

KW - Female

KW - Calcium Signaling

U2 - 10.1371/journal.pone.0053239

DO - 10.1371/journal.pone.0053239

M3 - Article (Academic Journal)

C2 - 23349704

SN - 1932-6203

VL - 8

SP - e53239

JO - PLOS ONE

JF - PLOS ONE

IS - 1

ER -

Absence of platelet phenotype in mice lacking the motor protein myosin Va

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