Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

Elizabeth Gray; Claire Rice; Helen Nightingale; Mark Ginty; Kelly Hares; Kevin Kemp; Nicki Cohen; Seth Love; Neil Scolding; Alastair Wilkins

doi:10.1177/1352458512451661

Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

Elizabeth Gray, Claire Rice, Helen Nightingale, Mark Ginty, Kelly Hares, Kevin Kemp, Nicki Cohen, Seth Love, Neil Scolding, Alastair Wilkins

Research output: Contribution to journal › Article (Academic Journal) › peer-review

23 Citations (Scopus)

Abstract

Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.

Original language	English
Pages (from-to)	153-161
Number of pages	9
Journal	Multiple Sclerosis Journal
Volume	19
Issue number	2
DOIs	https://doi.org/10.1177/1352458512451661
Publication status	Published - Feb 2013

Keywords

Paraffin Embedding
Humans
Aged
Neurodegenerative Diseases
Tissue Banks
Cerebral Cortex
Blotting, Western
Multiple Sclerosis
Phosphorylation
Aged, 80 and over
Neurons
Adult
Axons
Middle Aged
Female
Immunoenzyme Techniques
Male
Neurofilament Proteins

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title = "Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis",

abstract = "Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.",

keywords = "Paraffin Embedding, Humans, Aged, Neurodegenerative Diseases, Tissue Banks, Cerebral Cortex, Blotting, Western, Multiple Sclerosis, Phosphorylation, Aged, 80 and over, Neurons, Adult, Axons, Middle Aged, Female, Immunoenzyme Techniques, Male, Neurofilament Proteins",

author = "Elizabeth Gray and Claire Rice and Helen Nightingale and Mark Ginty and Kelly Hares and Kevin Kemp and Nicki Cohen and Seth Love and Neil Scolding and Alastair Wilkins",

year = "2013",

month = feb,

doi = "10.1177/1352458512451661",

language = "English",

volume = "19",

pages = "153--161",

journal = "Multiple Sclerosis Journal",

issn = "1477-0970",

publisher = "SAGE Publications Ltd",

number = "2",

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TY - JOUR

T1 - Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

AU - Gray, Elizabeth

AU - Rice, Claire

AU - Nightingale, Helen

AU - Ginty, Mark

AU - Hares, Kelly

AU - Kemp, Kevin

AU - Cohen, Nicki

AU - Love, Seth

AU - Scolding, Neil

AU - Wilkins, Alastair

PY - 2013/2

Y1 - 2013/2

N2 - Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.

AB - Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.

KW - Paraffin Embedding

KW - Humans

KW - Aged

KW - Neurodegenerative Diseases

KW - Tissue Banks

KW - Cerebral Cortex

KW - Blotting, Western

KW - Multiple Sclerosis

KW - Phosphorylation

KW - Aged, 80 and over

KW - Neurons

KW - Adult

KW - Axons

KW - Middle Aged

KW - Female

KW - Immunoenzyme Techniques

KW - Male

KW - Neurofilament Proteins

U2 - 10.1177/1352458512451661

DO - 10.1177/1352458512451661

M3 - Article (Academic Journal)

C2 - 22723571

SN - 1477-0970

VL - 19

SP - 153

EP - 161

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 2

ER -

Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

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Keywords

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