Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

Elizabeth Gray, Claire Rice, Helen Nightingale, Mark Ginty, Kelly Hares, Kevin Kemp, Nicki Cohen, Seth Love, Neil Scolding, Alastair Wilkins

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.
Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalMultiple Sclerosis Journal
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Paraffin Embedding
  • Humans
  • Aged
  • Neurodegenerative Diseases
  • Tissue Banks
  • Cerebral Cortex
  • Blotting, Western
  • Multiple Sclerosis
  • Phosphorylation
  • Aged, 80 and over
  • Neurons
  • Adult
  • Axons
  • Middle Aged
  • Female
  • Immunoenzyme Techniques
  • Male
  • Neurofilament Proteins

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