Abstract
Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 153-161 |
| Number of pages | 9 |
| Journal | Multiple Sclerosis Journal |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
Research Groups and Themes
- Cerebrovascular and Dementia Research Group
Keywords
- Paraffin Embedding
- Humans
- Aged
- Neurodegenerative Diseases
- Tissue Banks
- Cerebral Cortex
- Blotting, Western
- Multiple Sclerosis
- Phosphorylation
- Aged, 80 and over
- Neurons
- Adult
- Axons
- Middle Aged
- Female
- Immunoenzyme Techniques
- Male
- Neurofilament Proteins
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