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Abstract
Aim: To assess the accuracy and technical characteristics of CYP2C19 point of care tests (POCTs).
Patients & methods: Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting CYP2C19 loss of function (LOF) alleles.
Results: Eleven studies provided accuracy data (eight Spartan; one Genomadix Cube; one GMEX; one Genedrive). The POCTs had very high sensitivity and specificity for the alleles they tested for. Twenty-two studies reported technical characteristics: POCTs were easy to operate and provided results quickly. Limited data were reported for test failure rate and cost.
Conclusion: CYP2C19 POCTs may be a useful alternative to laboratory-based testing to guide antiplatelet therapy. Further data are required on accuracy (GMEX; Genedrive), test failure and cost (all POCT).
Patients & methods: Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting CYP2C19 loss of function (LOF) alleles.
Results: Eleven studies provided accuracy data (eight Spartan; one Genomadix Cube; one GMEX; one Genedrive). The POCTs had very high sensitivity and specificity for the alleles they tested for. Twenty-two studies reported technical characteristics: POCTs were easy to operate and provided results quickly. Limited data were reported for test failure rate and cost.
Conclusion: CYP2C19 POCTs may be a useful alternative to laboratory-based testing to guide antiplatelet therapy. Further data are required on accuracy (GMEX; Genedrive), test failure and cost (all POCT).
| Original language | English |
|---|---|
| Pages (from-to) | 407-423 |
| Number of pages | 17 |
| Journal | Pharmacogenomics |
| Volume | 25 |
| Issue number | 8-9 |
| Early online date | 4 Sept 2024 |
| DOIs | |
| Publication status | Published - 1 Feb 2025 |
Bibliographical note
Publisher Copyright:© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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Bristol TAG
Whiting, P. F. (Co-Principal Investigator), Welton, N. J. (Co-Principal Investigator), Owen-Smith, A. L. (Co-Investigator), Phillippo, D. M. (Co-Investigator), Caldwell, D. (Co-Investigator), Marques, E. M. R. (Co-Investigator), Jones, H. E. (Co-Investigator), Thom, H. H. Z. (Co-Investigator), Pedder, H. (Co-Investigator), Savovic, J. (Co-Investigator), Higgins, J. P. T. (Co-Investigator), Sadek, A. (Co-Investigator), Lopez Manzano, C. (Co-Investigator), Cooper, C. (Co-Investigator), Tomlinson, E. (Co-Investigator), Carroll, J. S. (Co-Investigator), Walker, J. G. (Co-Investigator), Ward, M. E. (Co-Investigator) & James, R. M. (Co-Investigator)
1/04/22 → 31/03/27
Project: Research, Parent
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