Projects per year
Abstract
Endosomes constitute major sorting compartments within the cell. There, a myriad of transmembrane proteins (cargoes) are delivered to the lysosome for degradation or retrieved from this fate and recycled through tubulo-vesicular transport carriers to different cellular destinations. Retrieval and recycling are orchestrated by multi-protein assemblies that include retromer and retriever, sorting nexins, and the Arp2/3 activating WASH complex. Fine-tuned control of actin polymerization on endosomes is fundamental for the retrieval and recycling of cargoes. Recent advances in the field have highlighted several roles that actin plays in this process including the binding to cargoes, stabilization of endosomal subdomains, generation of the remodeling forces required for the biogenesis of cargo-enriched transport carriers and short-range motility of the transport carriers.
Original language | English |
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Pages (from-to) | 22-33 |
Number of pages | 12 |
Journal | Current Opinion in Cell Biology |
Volume | 56 |
Early online date | 15 Sept 2018 |
DOIs | |
Publication status | Published - Feb 2019 |
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Dive into the research topics of 'Actin-dependent endosomal receptor recycling'. Together they form a unique fingerprint.Projects
- 1 Finished
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Defining the role of retromer-like in endosomal cargo sorting in health and disease
Cullen , P. J. (Principal Investigator)
1/10/17 → 31/03/24
Project: Research