Actin protects mammalian eggs against chromosome segregation errors

Binyam Mogessie, Melina Schuh

Research output: Contribution to journalArticle (Academic Journal)peer-review

345 Downloads (Pure)

Abstract

Chromosome segregation is driven by a spindle that is made of microtubules but is generally thought to be independent of actin. Here, we report an unexpected actin-dependent mechanism that drives the accurate alignment and segregation of chromosomes in mammalian eggs. Prominent actin filaments permeated the microtubule spindle in eggs of several mammalian species, including humans. Disrupting actin in mouse eggs led to significantly increased numbers of misaligned chromosomes as well as lagging chromosomes during meiosis I and II. We found that actin drives accurate chromosome segregation by promoting the formation of functional kinetochore fibers, the microtubule bundles that align and segregate the chromosomes. Thus, actin is essential to prevent chromosome segregation errors in eggs, which are a leading cause of miscarriages, infertility, and Down syndrome.

Original languageEnglish
Article numbereaal1647
JournalScience
Volume357
Issue number6353
DOIs
Publication statusPublished - 25 Aug 2017

Keywords

  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Actin protects mammalian eggs against chromosome segregation errors'. Together they form a unique fingerprint.

Cite this