Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle

A K MASTERS, H HUDDART, A M HETHERINGTON

Research output: Contribution to journalArticle (Academic Journal)

Abstract

1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity.

2. The Ca2+ agonist BAY K8644 significantry enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed.

3. At 10(-7) mol l(-1) ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations.

4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens.

5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalGeneral Pharmacology
Volume25
Issue number3
Publication statusPublished - May 1994

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