Activation by sub-stoichiometric inhibition

Melisa Merdanovic, Steven G Burston, Anna Laura Schmitz, Steffen Köcher, Stefan Knapp, Tim Clausen, Markus Kaiser, Robert Huber, Michael Ehrmann

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Original languageEnglish
Pages (from-to)1414-1418
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume117
Issue number3
Early online date6 Jan 2020
DOIs
Publication statusPublished - 21 Jan 2020

Keywords

  • HtrA protease
  • allostery
  • cooperativity
  • HTRA1
  • inhibitor

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    This is the author accepted manuscript (AAM). The final published version (version of record) is available online via National Academy of Sciences at https://doi.org/10.1073/pnas.1918721117 . Please refer to any applicable terms of use of the publisher.

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  • Supplementary information PDF

    This is the author accepted manuscript (AAM). The final published version (version of record) is available online via National Academy of Sciences at https://doi.org/10.1073/pnas.1918721117. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 3.77 MB

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Merdanovic, M., Burston, S. G., Schmitz, A. L., Köcher, S., Knapp, S., Clausen, T., Kaiser, M., Huber, R., & Ehrmann, M. (2020). Activation by sub-stoichiometric inhibition. Proceedings of the National Academy of Sciences of the United States of America, 117(3), 1414-1418. https://doi.org/10.1073/pnas.1918721117