Activation of glutamate metabotropic receptors induces long-term potentiation

ZA Bortolotto, GL Collingridge

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.
Translated title of the contributionActivation of glutamate metabotropic receptors induces long-term potentiation
Original languageEnglish
Pages (from-to)297 - 298
Number of pages2
JournalEuropean Journal of Pharmacology
Volume214
DOIs
Publication statusPublished - Apr 1992

Fingerprint Dive into the research topics of 'Activation of glutamate metabotropic receptors induces long-term potentiation'. Together they form a unique fingerprint.

Cite this