Activation of glutamate metabotropic receptors induces long-term potentiation

ZA Bortolotto; GL Collingridge

doi:10.1016/i.ejphar.2010.098.059

Activation of glutamate metabotropic receptors induces long-term potentiation

ZA Bortolotto, GL Collingridge

School of Physiology, Pharmacology & Neuroscience

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.

Translated title of the contribution	Activation of glutamate metabotropic receptors induces long-term potentiation
Original language	English
Pages (from-to)	297 - 298
Number of pages	2
Journal	European Journal of Pharmacology
Volume	214
DOIs	https://doi.org/10.1016/i.ejphar.2010.098.059
Publication status	Published - Apr 1992

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title = "Activation of glutamate metabotropic receptors induces long-term potentiation",

abstract = "The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.",

author = "ZA Bortolotto and GL Collingridge",

year = "1992",

month = apr,

doi = "10.1016/i.ejphar.2010.098.059",

language = "English",

volume = "214",

pages = "297 -- 298",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "North-Holland Publishing Company",

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TY - JOUR

T1 - Activation of glutamate metabotropic receptors induces long-term potentiation

AU - Bortolotto, ZA

AU - Collingridge, GL

PY - 1992/4

Y1 - 1992/4

N2 - The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.

AB - The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.

U2 - 10.1016/i.ejphar.2010.098.059

DO - 10.1016/i.ejphar.2010.098.059

M3 - Article (Academic Journal)

VL - 214

SP - 297

EP - 298

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

ER -