The possibility of trailing edge noise reduction using active flow control is addressed in this paper. The boundary layer is altered with the help of uniform perpendicular and inclined flow injection and suction on a long flat plate upstream of a sharp trailing edge. The flow quantities have been measured using particle image velocimetry, hot-wire anemometry, and the surface pressure fluctuations using flush mounted miniature pressure transducers. It was shown that the proposed flow control methods are capable of reducing the noise over a wide range of frequencies. It was also revealed that the perpendicular blowing is effective in shifting the energy containing turbulent structures away from the wall, resulting in a significant reduction in the surface pressure spectra. The inclined blowing control method was capable of further reducing the surface pressure spectra, while maintaining low input power requirement. The perpendicular suction control was shown to be effective in the reduction of pressure fluctuations in the mid frequency regions, which quickly penetrates to the lower frequency downstream. The inclined suction control has also lead to significant reductions in the surface pressure fluctuations over a wide range of frequencies, while the required suction rate was kept considerably low. It has also been shown that the proposed active flow control methods can reduce the spanwise correlation length of the turbulent structures near the trailing edge. In general, results have shown that all proposed active flow control techniques can effectively alter the boundary layer structure and reduce trailing edge noise.