Acute disseminated encephalomyelitis and other inflammatory demyelinating variants

Neil Scolding

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)


Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory central nervous system disorder characterized by acute or subacute onset of multifocal neurologic deficits with headache and impaired conscious level. Acute haemorrhagic leuoko-encephalitis (AHEM) is a more sever, often fatal variant. These disorders often follows a viral illness or vaccination, and are usually monophasic, though (probably more commonly in childhood) a multiphasic variant of ADEM is recognized. Because of the relative non-specificity of the clinical presentation (a sub-acute encephalopathy with focal signs), the differential diagnosis is wide; and distinction from the first episode of relapsing-remitting multiple sclerosis can occasionally be difficult. Here the clinical and investigational features of these disorders and their treatment are discussed.

Original languageEnglish
Pages (from-to)601-11
Number of pages11
JournalHandbook of Clinical Neurology
Publication statusPublished - 2014


  • Demyelinating Diseases
  • Diagnosis, Differential
  • Encephalomyelitis, Acute Disseminated
  • Humans
  • Prognosis
  • Secondary Prevention
  • Vaccination


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