Acute infective exacerbations of chronic bronchitis

P Ball, J M Harris, D Lowson, G Tillotson, R Wilson

Research output: Contribution to journalArticle (Academic Journal)peer-review

202 Citations (Scopus)

Abstract

Patients with an acute infective exacerbation of chronic bronchitis (AECB) (n = 471) were enrolled into a computer-based general-practice study to determine whether features of past history, presenting symptoms, or findings on examination were predictive of failure to recover. The median age was 68, 56.3% were male, and 82% were current or ex-smokers. All had daily sputum production and 57.5% had moderate or severe airflow obstruction. During the AECB 11.5% were pyrexial, and 80.7% had abnormal auscultatory findings; about half had moderate to severe increases in dyspnoea and airflow obstruction, and the majority had increases in sputum volume and/or purulence. The median number of AECBs in the previous year was three, and one-third of patients had cardiopulmonary disease. The only factors significantly (p < 0.05) predicting failure to recover from an AECB were historical. Neither clinical features at presentation nor antibiotic treatment affected recovery. Coexistent cardiopulmonary disease was a risk factor for returning with a chest problem and for being referred to hospital. The number of chest infections in the previous 12 months was a risk factor for returning with a chest problem. The higher the number of chest infections, the higher the odds of returning with a chest problem. The best combination predicting return with a chest problem was history of cardiopulmonary disease and more than four previous AECBs in the last 12 months. The sensitivity was 75% and specificity 47%.

Original languageEnglish
Pages (from-to)61-8
Number of pages8
JournalQJM
Volume88
Issue number1
Publication statusPublished - Jan 1995

Keywords

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Infections
  • Bronchitis
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Smoking
  • Sputum

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