Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.

F.E. Watt, E. Paterson, A. Freidin, M. Kenny, A. Judge, J. Saklatvala, A. Williams, T.L. Vincent

Research output: Contribution to journalArticle (Academic Journal)peer-review

239 Downloads (Pure)

Abstract

To investigate whether molecules found to be up-regulated within hours of surgical joint destabilization in the mouse are also elevated in the analogous human setting of acute knee injury, how this molecular response varies between individuals, and whether it is related to patient-reported outcomes in the 3 months after injury.Seven candidate molecules were analyzed in blood and synovial fluid (SF) from 150 participants with recent structural knee injury at baseline (
Original languageEnglish
Pages (from-to)2129-2140
Number of pages12
JournalArthritis and Rheumatology
Volume68
Issue number9
Early online date25 Aug 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Synovial Fluid
  • Animals
  • Humans
  • Mice
  • Knee Injuries
  • Treatment Outcome
  • Time Factors
  • Adolescent
  • Adult
  • Middle Aged
  • Female
  • Male
  • Young Adult
  • Biomarkers

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