Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.

F.E. Watt; E. Paterson; A. Freidin; M. Kenny; A. Judge; J. Saklatvala; A. Williams; T.L. Vincent

doi:10.1002/art.39677

Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.

F.E. Watt, E. Paterson, A. Freidin, M. Kenny, A. Judge, J. Saklatvala, A. Williams, T.L. Vincent

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

To investigate whether molecules found to be up-regulated within hours of surgical joint destabilization in the mouse are also elevated in the analogous human setting of acute knee injury, how this molecular response varies between individuals, and whether it is related to patient-reported outcomes in the 3 months after injury.Seven candidate molecules were analyzed in blood and synovial fluid (SF) from 150 participants with recent structural knee injury at baseline (

Original language	English
Pages (from-to)	2129-2140
Number of pages	12
Journal	Arthritis and Rheumatology
Volume	68
Issue number	9
Early online date	25 Aug 2016
DOIs	https://doi.org/10.1002/art.39677
Publication status	Published - Sept 2016

Keywords

Synovial Fluid
Animals
Humans
Mice
Knee Injuries
Treatment Outcome
Time Factors
Adolescent
Adult
Middle Aged
Female
Male
Young Adult
Biomarkers

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10.1002/art.39677

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AU - Watt, F.E.

AU - Paterson, E.

AU - Freidin, A.

AU - Kenny, M.

AU - Judge, A.

AU - Saklatvala, J.

AU - Williams, A.

AU - Vincent, T.L.

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AB - To investigate whether molecules found to be up-regulated within hours of surgical joint destabilization in the mouse are also elevated in the analogous human setting of acute knee injury, how this molecular response varies between individuals, and whether it is related to patient-reported outcomes in the 3 months after injury.Seven candidate molecules were analyzed in blood and synovial fluid (SF) from 150 participants with recent structural knee injury at baseline (

KW - Synovial Fluid

KW - Animals

KW - Humans

KW - Mice

KW - Knee Injuries

KW - Treatment Outcome

KW - Time Factors

KW - Adolescent

KW - Adult

KW - Middle Aged

KW - Female

KW - Male

KW - Young Adult

KW - Biomarkers

UR - https://ora.ox.ac.uk/objects/pubs:611582

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M3 - Article (Academic Journal)

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SN - 2326-5191

VL - 68

SP - 2129

EP - 2140

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

IS - 9

ER -

Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.

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