TY - JOUR
T1 - Addition of candesartan to angiotensin converting enzyme inhibitor therapy in patients with chronic heart failure does not reduce levels of oxidative stress
AU - Ellis, Gethin R
AU - Nightingale, Angus K
AU - Blackman, Daniel J
AU - Anderson, Richard A
AU - Mumford, Catherine
AU - Timmins, Graham
AU - Lang, Derek
AU - Jackson, Simon K
AU - Penney, Michael D
AU - Lewis, Malcolm J
AU - Frenneaux, Michael P
AU - Morris-Thurgood, Jayne
PY - 2002
Y1 - 2002
N2 - Angiotensin II exerts a number of harmful effects in patients with chronic heart failure (CHF) and, through an increase in oxidative stress, is thought to be critical in the development of endothelial dysfunction. Angiotensin II may be elevated in CHF despite treatment with angiotensin converting enzyme (ACE) inhibitors, producing a rationale for adjunctive angiotensin receptor blockade. We investigated whether the addition of angiotensin antagonism to ACE inhibition would reduce oxidative stress and improve endothelial function and exercise tolerance in patients with chronic heart failure.
AB - Angiotensin II exerts a number of harmful effects in patients with chronic heart failure (CHF) and, through an increase in oxidative stress, is thought to be critical in the development of endothelial dysfunction. Angiotensin II may be elevated in CHF despite treatment with angiotensin converting enzyme (ACE) inhibitors, producing a rationale for adjunctive angiotensin receptor blockade. We investigated whether the addition of angiotensin antagonism to ACE inhibition would reduce oxidative stress and improve endothelial function and exercise tolerance in patients with chronic heart failure.
M3 - Article (Academic Journal)
C2 - 11959049
VL - 4
SP - 193
EP - 199
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 2
ER -