Addition of lithiated tertiary aromatic amides to epoxides and aziridines: Asymmetric synthesis of (S)-(+)-mellein

Jonathan Clayden*, Christopher C. Stimson, Madeleine Helliwell, Martine Keenan

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)

Abstract

Addition of ortholithiated or laterally lithiated amides to epoxides or aziridines provides, in some cases stereoselectively, products which may cyclise to yield benzopyranones in good enantiomeric excess.

Original languageEnglish
Pages (from-to)873-876
Number of pages4
JournalSYNLETT
Issue number6
Early online date14 Mar 2006
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Benzopyranone
  • Directed metallation
  • Epoxide
  • Isochromanone
  • Lithiation
  • Synthesis

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