Saturated and unsaturated β- and δ-hydroxyalkyldiphenylphosphine oxides give adducts with aldehydes after treatment with an excess of butyllithium. Normal Horner-Wittig reactions lead to O-trityl (E,E)- and (E,Z)-hepta-2,4-dien-1-ols. Allylic rearrangement of the corresponding acetates catalysed by PdII can be used to control remote (1,4 or 1,7) relative stereochemistry across E alkenes.
|Number of pages||11|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - 1 Dec 1994|