TY - JOUR
T1 - Adiponectin and lipid profiles compared with insulins in relation to early growth of British South Asian and European children
T2 - the Manchester children's growth and vascular health study
AU - Bansal, Narinder
AU - Anderson, Simon G
AU - Vyas, Avni
AU - Gemmell, Isla
AU - Charlton-Menys, Valentine
AU - Oldroyd, John
AU - Pemberton, Philip
AU - Durrington, Paul N
AU - Clayton, Peter E
AU - Cruickshank, J Kennedy
PY - 2011/8
Y1 - 2011/8
N2 - CONTEXT: Adiponectin, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations may be important in the pathophysiology of cardiovascular disease.OBJECTIVE: We tested the hypothesis that serum adiponectin rather than insulin differs from early life, between South Asians and Europeans, with a potentially key role in excess cardiovascular risk characteristic of adult South Asians.DESIGN AND PARTICIPANTS: We conducted a longitudinal study of 215 British-born children of European (n = 138) and South Asian (n = 77) origin, from birth to 3 yr.MAIN OUTCOME MEASURE: Serum adiponectin, insulin, proinsulin and HDL-C concentrations were assessed in relation to ethnic group and growth in anthropometric variables from 0-3 yr of age.RESULTS: Serum adiponectin was lower in South Asian children, despite their smaller size, notable at age 3-6 months (9.5 vs. 11.8 mg/liter; P = 0.04), with no ethnic differences in serum lipids or insulin or proinsulin. In mixed-effects longitudinal models for HDL-C, determinants were adiponectin (P = 0.034), age (P < 0.001), and body mass index (P < 0.001) but not ethnicity. None of these or growth variables affected either insulin or proinsulin. In a fully adjusted mixed-effects longitudinal model including age, sex, insulin, and proinsulin, the independent determinants of serum adiponectin were height [21.3 (95% confidence interval = 31.7-10.8 cm lower, for every 1 mmol/liter increase in adiponectin, P < 0.001], HDL-C [2.8 (1.3-4.2) mmol/liter higher, P < 0.0001], body mass index (lower, P = 0.03), and South Asian ethnicity (lower, P = 0.01).CONCLUSIONS: These British South Asian-origin infants have lower serum adiponectin but no differences in HDL-C or insulin molecules. In South Asians, factors affecting adiponectin metabolism in early life, rather than insulin resistance, likely determine later excess cardiovascular risk.
AB - CONTEXT: Adiponectin, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations may be important in the pathophysiology of cardiovascular disease.OBJECTIVE: We tested the hypothesis that serum adiponectin rather than insulin differs from early life, between South Asians and Europeans, with a potentially key role in excess cardiovascular risk characteristic of adult South Asians.DESIGN AND PARTICIPANTS: We conducted a longitudinal study of 215 British-born children of European (n = 138) and South Asian (n = 77) origin, from birth to 3 yr.MAIN OUTCOME MEASURE: Serum adiponectin, insulin, proinsulin and HDL-C concentrations were assessed in relation to ethnic group and growth in anthropometric variables from 0-3 yr of age.RESULTS: Serum adiponectin was lower in South Asian children, despite their smaller size, notable at age 3-6 months (9.5 vs. 11.8 mg/liter; P = 0.04), with no ethnic differences in serum lipids or insulin or proinsulin. In mixed-effects longitudinal models for HDL-C, determinants were adiponectin (P = 0.034), age (P < 0.001), and body mass index (P < 0.001) but not ethnicity. None of these or growth variables affected either insulin or proinsulin. In a fully adjusted mixed-effects longitudinal model including age, sex, insulin, and proinsulin, the independent determinants of serum adiponectin were height [21.3 (95% confidence interval = 31.7-10.8 cm lower, for every 1 mmol/liter increase in adiponectin, P < 0.001], HDL-C [2.8 (1.3-4.2) mmol/liter higher, P < 0.0001], body mass index (lower, P = 0.03), and South Asian ethnicity (lower, P = 0.01).CONCLUSIONS: These British South Asian-origin infants have lower serum adiponectin but no differences in HDL-C or insulin molecules. In South Asians, factors affecting adiponectin metabolism in early life, rather than insulin resistance, likely determine later excess cardiovascular risk.
KW - Adiponectin
KW - Asia
KW - Asian Continental Ancestry Group
KW - Cardiovascular Diseases
KW - Child Development
KW - Child, Preschool
KW - Cholesterol, HDL
KW - England
KW - European Continental Ancestry Group
KW - Female
KW - Humans
KW - Infant
KW - Infant Welfare
KW - Infant, Newborn
KW - Insulin
KW - Male
KW - Risk Factors
KW - Triglycerides
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1210/jc.2011-0046
DO - 10.1210/jc.2011-0046
M3 - Article (Academic Journal)
C2 - 21632814
SN - 0021-972X
VL - 96
SP - 2567
EP - 2574
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 8
ER -
