Adiponectin and lipid profiles compared with insulins in relation to early growth of British South Asian and European children: the Manchester children's growth and vascular health study

Narinder Bansal, Simon G Anderson, Avni Vyas, Isla Gemmell, Valentine Charlton-Menys, John Oldroyd, Philip Pemberton, Paul N Durrington, Peter E Clayton, J Kennedy Cruickshank

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Abstract

CONTEXT: Adiponectin, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations may be important in the pathophysiology of cardiovascular disease.

OBJECTIVE: We tested the hypothesis that serum adiponectin rather than insulin differs from early life, between South Asians and Europeans, with a potentially key role in excess cardiovascular risk characteristic of adult South Asians.

DESIGN AND PARTICIPANTS: We conducted a longitudinal study of 215 British-born children of European (n = 138) and South Asian (n = 77) origin, from birth to 3 yr.

MAIN OUTCOME MEASURE: Serum adiponectin, insulin, proinsulin and HDL-C concentrations were assessed in relation to ethnic group and growth in anthropometric variables from 0-3 yr of age.

RESULTS: Serum adiponectin was lower in South Asian children, despite their smaller size, notable at age 3-6 months (9.5 vs. 11.8 mg/liter; P = 0.04), with no ethnic differences in serum lipids or insulin or proinsulin. In mixed-effects longitudinal models for HDL-C, determinants were adiponectin (P = 0.034), age (P < 0.001), and body mass index (P < 0.001) but not ethnicity. None of these or growth variables affected either insulin or proinsulin. In a fully adjusted mixed-effects longitudinal model including age, sex, insulin, and proinsulin, the independent determinants of serum adiponectin were height [21.3 (95% confidence interval = 31.7-10.8 cm lower, for every 1 mmol/liter increase in adiponectin, P < 0.001], HDL-C [2.8 (1.3-4.2) mmol/liter higher, P < 0.0001], body mass index (lower, P = 0.03), and South Asian ethnicity (lower, P = 0.01).

CONCLUSIONS: These British South Asian-origin infants have lower serum adiponectin but no differences in HDL-C or insulin molecules. In South Asians, factors affecting adiponectin metabolism in early life, rather than insulin resistance, likely determine later excess cardiovascular risk.

Original languageEnglish
Pages (from-to)2567-74
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Adiponectin
  • Asia
  • Asian Continental Ancestry Group
  • Cardiovascular Diseases
  • Child Development
  • Child, Preschool
  • Cholesterol, HDL
  • England
  • European Continental Ancestry Group
  • Female
  • Humans
  • Infant
  • Infant Welfare
  • Infant, Newborn
  • Insulin
  • Male
  • Risk Factors
  • Triglycerides
  • Journal Article
  • Research Support, Non-U.S. Gov't

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