Adipose and Height Growth Through Childhood and Blood Pressure Status in a Large Prospective Cohort Study

Alexander Jones*, Marietta Charakida, Emanuela Falaschetti, Aroon D. Hingorani, Nicholas Finer, Stefano Masi, Ann E. Donald, Debbie A. Lawlor, George Davey Smith, John E. Deanfield

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

63 Citations (Scopus)

Abstract

Raised blood pressure (BP) is the world's leading mortality risk factor. Childhood BP substantially predicts adult levels, and although both prenatal and postnatal growth influence it, their relative importance is debated. In a longitudinal study (Avon Longitudinal Study of Parents and Children) of 12 962 healthy children, we aimed to assess the relative contribution of different growth periods and of standardized measures of height versus weight-for-height (an adiposity marker) to BP at age 10 years. Conditional growth modeling was used in the 3230 boys and 3346 girls with BP measurements. Systolic BP was inversely associated with birth weight and weight-for-height but not length (-0.33, -0.27, and 0.12 mm Hg . SD-1; P=0.003, 0.035, and 0.35, respectively). In infancy, weight, weight-for-height, and height gains were all positively associated with systolic BP (0.90, 0.41, and 0.82 mm Hg SD-1, respectively; all P

Original languageEnglish
Pages (from-to)919-+
Number of pages13
JournalHypertension
Volume59
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • blood pressure
  • childhood growth
  • hypertension
  • obesity
  • population
  • CORONARY-HEART-DISEASE
  • OF-THE-LITERATURE
  • FETAL ORIGINS
  • RISK-FACTORS
  • UNEXPLAINED RESIDUALS
  • ADULT DISEASE
  • WEIGHT-GAIN
  • HYPOTHESIS
  • CHILDREN
  • BIRTH

Cite this