Adipose and Height Growth Through Childhood and Blood Pressure Status in a Large Prospective Cohort Study

Alexander Jones; Marietta Charakida; Emanuela Falaschetti; Aroon D. Hingorani; Nicholas Finer; Stefano Masi; Ann E. Donald; Debbie A. Lawlor; George Davey Smith; John E. Deanfield

doi:10.1161/HYPERTENSIONAHA.111.187716

Adipose and Height Growth Through Childhood and Blood Pressure Status in a Large Prospective Cohort Study

Alexander Jones^*, Marietta Charakida, Emanuela Falaschetti, Aroon D. Hingorani, Nicholas Finer, Stefano Masi, Ann E. Donald, Debbie A. Lawlor, George Davey Smith, John E. Deanfield

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

79 Citations (Scopus)

Abstract

Raised blood pressure (BP) is the world's leading mortality risk factor. Childhood BP substantially predicts adult levels, and although both prenatal and postnatal growth influence it, their relative importance is debated. In a longitudinal study (Avon Longitudinal Study of Parents and Children) of 12 962 healthy children, we aimed to assess the relative contribution of different growth periods and of standardized measures of height versus weight-for-height (an adiposity marker) to BP at age 10 years. Conditional growth modeling was used in the 3230 boys and 3346 girls with BP measurements. Systolic BP was inversely associated with birth weight and weight-for-height but not length (-0.33, -0.27, and 0.12 mm Hg . SD-1; P=0.003, 0.035, and 0.35, respectively). In infancy, weight, weight-for-height, and height gains were all positively associated with systolic BP (0.90, 0.41, and 0.82 mm Hg SD-1, respectively; all P

Original language	English
Pages (from-to)	919-+
Number of pages	13
Journal	Hypertension
Volume	59
Issue number	5
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.111.187716
Publication status	Published - May 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

blood pressure
childhood growth
hypertension
obesity
population
CORONARY-HEART-DISEASE
OF-THE-LITERATURE
FETAL ORIGINS
RISK-FACTORS
UNEXPLAINED RESIDUALS
ADULT DISEASE
WEIGHT-GAIN
HYPOTHESIS
CHILDREN
BIRTH

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10.1161/HYPERTENSIONAHA.111.187716

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Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
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title = "Adipose and Height Growth Through Childhood and Blood Pressure Status in a Large Prospective Cohort Study",

abstract = "Raised blood pressure (BP) is the world's leading mortality risk factor. Childhood BP substantially predicts adult levels, and although both prenatal and postnatal growth influence it, their relative importance is debated. In a longitudinal study (Avon Longitudinal Study of Parents and Children) of 12 962 healthy children, we aimed to assess the relative contribution of different growth periods and of standardized measures of height versus weight-for-height (an adiposity marker) to BP at age 10 years. Conditional growth modeling was used in the 3230 boys and 3346 girls with BP measurements. Systolic BP was inversely associated with birth weight and weight-for-height but not length (-0.33, -0.27, and 0.12 mm Hg . SD-1; P=0.003, 0.035, and 0.35, respectively). In infancy, weight, weight-for-height, and height gains were all positively associated with systolic BP (0.90, 0.41, and 0.82 mm Hg SD-1, respectively; all P",

keywords = "blood pressure, childhood growth, hypertension, obesity, population, CORONARY-HEART-DISEASE, OF-THE-LITERATURE, FETAL ORIGINS, RISK-FACTORS, UNEXPLAINED RESIDUALS, ADULT DISEASE, WEIGHT-GAIN, HYPOTHESIS, CHILDREN, BIRTH",

author = "Alexander Jones and Marietta Charakida and Emanuela Falaschetti and Hingorani, \{Aroon D.\} and Nicholas Finer and Stefano Masi and Donald, \{Ann E.\} and Lawlor, \{Debbie A.\} and Smith, \{George Davey\} and Deanfield, \{John E.\}",

year = "2012",

month = may,

doi = "10.1161/HYPERTENSIONAHA.111.187716",

language = "English",

volume = "59",

pages = "919--+",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams and Wilkins",

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AU - Jones, Alexander

AU - Charakida, Marietta

AU - Falaschetti, Emanuela

AU - Hingorani, Aroon D.

AU - Finer, Nicholas

AU - Masi, Stefano

AU - Donald, Ann E.

AU - Lawlor, Debbie A.

AU - Smith, George Davey

AU - Deanfield, John E.

PY - 2012/5

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N2 - Raised blood pressure (BP) is the world's leading mortality risk factor. Childhood BP substantially predicts adult levels, and although both prenatal and postnatal growth influence it, their relative importance is debated. In a longitudinal study (Avon Longitudinal Study of Parents and Children) of 12 962 healthy children, we aimed to assess the relative contribution of different growth periods and of standardized measures of height versus weight-for-height (an adiposity marker) to BP at age 10 years. Conditional growth modeling was used in the 3230 boys and 3346 girls with BP measurements. Systolic BP was inversely associated with birth weight and weight-for-height but not length (-0.33, -0.27, and 0.12 mm Hg . SD-1; P=0.003, 0.035, and 0.35, respectively). In infancy, weight, weight-for-height, and height gains were all positively associated with systolic BP (0.90, 0.41, and 0.82 mm Hg SD-1, respectively; all P

AB - Raised blood pressure (BP) is the world's leading mortality risk factor. Childhood BP substantially predicts adult levels, and although both prenatal and postnatal growth influence it, their relative importance is debated. In a longitudinal study (Avon Longitudinal Study of Parents and Children) of 12 962 healthy children, we aimed to assess the relative contribution of different growth periods and of standardized measures of height versus weight-for-height (an adiposity marker) to BP at age 10 years. Conditional growth modeling was used in the 3230 boys and 3346 girls with BP measurements. Systolic BP was inversely associated with birth weight and weight-for-height but not length (-0.33, -0.27, and 0.12 mm Hg . SD-1; P=0.003, 0.035, and 0.35, respectively). In infancy, weight, weight-for-height, and height gains were all positively associated with systolic BP (0.90, 0.41, and 0.82 mm Hg SD-1, respectively; all P

KW - blood pressure

KW - childhood growth

KW - hypertension

KW - obesity

KW - population

KW - CORONARY-HEART-DISEASE

KW - OF-THE-LITERATURE

KW - FETAL ORIGINS

KW - RISK-FACTORS

KW - UNEXPLAINED RESIDUALS

KW - ADULT DISEASE

KW - WEIGHT-GAIN

KW - HYPOTHESIS

KW - CHILDREN

KW - BIRTH

U2 - 10.1161/HYPERTENSIONAHA.111.187716

DO - 10.1161/HYPERTENSIONAHA.111.187716

M3 - Article (Academic Journal)

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JO - Hypertension

JF - Hypertension

IS - 5

ER -

Adipose and Height Growth Through Childhood and Blood Pressure Status in a Large Prospective Cohort Study

Abstract

UN SDGs

Keywords

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