Adult Brain Tumour Research in 2024: Status, Challenges and Recommendations

Karin Purshouse; Helen J Bulbeck; Alasdair G. Rooney; Karen Noble; Ross D Carruthers; Gerard Thompson; Petra Hamerlik; Christina Yap; Kathreena M Kurian; Sarah Jefferies; Juanita S Lopez; Michael D Jenkinson; C Oliver Hanemann; Lucy F Stead

doi:10.1111/nan.12979

Adult Brain Tumour Research in 2024: Status, Challenges and Recommendations

Karin Purshouse, Helen J Bulbeck, Alasdair G. Rooney, Karen Noble, Ross D Carruthers, Gerard Thompson, Petra Hamerlik, Christina Yap, Kathreena M Kurian, Sarah Jefferies, Juanita S Lopez, Michael D Jenkinson, C Oliver Hanemann, Lucy F Stead^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which span the research spectrum from bench to bedside and back again. We discuss the status, challenges and recommendations for each one, specific to the United Kingdom.

Original language	English
Article number	e12979
Number of pages	14
Journal	Neuropathology and Applied Neurobiology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1111/nan.12979
Publication status	Published - 11 Apr 2024

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© 2024 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.

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Bristol Population Health Science Institute

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Purshouse, K., Bulbeck, H. J., Rooney, A. G., Noble, K., Carruthers, R. D., Thompson, G., Hamerlik, P., Yap, C., Kurian, K. M., Jefferies, S., Lopez, J. S., Jenkinson, M. D., Hanemann, C. O., & Stead, L. F. (2024). Adult Brain Tumour Research in 2024: Status, Challenges and Recommendations. Neuropathology and Applied Neurobiology, 50(2), Article e12979. https://doi.org/10.1111/nan.12979

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title = "Adult Brain Tumour Research in 2024: Status, Challenges and Recommendations",

abstract = "In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which span the research spectrum from bench to bedside and back again. We discuss the status, challenges and recommendations for each one, specific to the United Kingdom.",

author = "Karin Purshouse and Bulbeck, {Helen J} and Rooney, {Alasdair G.} and Karen Noble and Carruthers, {Ross D} and Gerard Thompson and Petra Hamerlik and Christina Yap and Kurian, {Kathreena M} and Sarah Jefferies and Lopez, {Juanita S} and Jenkinson, {Michael D} and Hanemann, {C Oliver} and Stead, {Lucy F}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.",

year = "2024",

month = apr,

day = "11",

doi = "10.1111/nan.12979",

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AU - Purshouse, Karin

AU - Bulbeck, Helen J

AU - Rooney, Alasdair G.

AU - Noble, Karen

AU - Carruthers, Ross D

AU - Thompson, Gerard

AU - Hamerlik, Petra

AU - Yap, Christina

AU - Kurian, Kathreena M

AU - Jefferies, Sarah

AU - Lopez, Juanita S

AU - Jenkinson, Michael D

AU - Hanemann, C Oliver

AU - Stead, Lucy F

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AB - In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which span the research spectrum from bench to bedside and back again. We discuss the status, challenges and recommendations for each one, specific to the United Kingdom.

U2 - 10.1111/nan.12979

DO - 10.1111/nan.12979

M3 - Article (Academic Journal)

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JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

IS - 2

M1 - e12979

ER -

Adult Brain Tumour Research in 2024: Status, Challenges and Recommendations

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