Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

David Wormser; Emanuele Di Angelantonio; Stephen Kaptoge; Angela M. Wood; Pei Gao; Qi Sun; Goeran Walldius; Randi Selmer; W. M. Monique Verschuren; H. Bas Bueno-de-Mesquita; Gunnar Engstrom; Paul M. Ridker; Inger Njolstad; Hiroyasu Iso; Ingar Holme; Simona Giampaoli; Hugh Tunstall-Pedoe; J. Michael Gaziano; Eric Brunner; Frank Kee; Alberto Tosetto; Christa Meisinger; Hermann Brenner; Pierre Ducimetiere; Peter H. Whincup; Robert W. Tipping; Ian Ford; Peter Cremer; Albert Hofman; Lars Wilhelmsen; Robert Clarke; Ian H. de Boer; J. Wouter Jukema; Alejandro Marin Ibanez; Debbie A. Lawlor; Ralph B. D'Agostino; Beatriz Rodriguez; Edoardo Casiglia; Coen D. A. Stehouwer; Leon A. Simons; Paul J. Nietert; Elizabeth Barrett-Connor; Demosthenes B. Panagiotakos; Cecilia Bjorkelund; Timo E. Strandberg; Sylvia Wassertheil-Smoller; Dan G. Blazer; James O. Taylor; Yoav Ben-Shlomo; George Davey Smith; Emerging Risk Factors Collaboration

doi:10.1093/ije/dys086

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

David Wormser, Emanuele Di Angelantonio, Stephen Kaptoge, Angela M. Wood, Pei Gao, Qi Sun, Goeran Walldius, Randi Selmer, W. M. Monique Verschuren, H. Bas Bueno-de-Mesquita, Gunnar Engstrom, Paul M. Ridker, Inger Njolstad, Hiroyasu Iso, Ingar Holme, Simona Giampaoli, Hugh Tunstall-Pedoe, J. Michael Gaziano, Eric Brunner, Frank KeeAlberto Tosetto, Christa Meisinger, Hermann Brenner, Pierre Ducimetiere, Peter H. Whincup, Robert W. Tipping, Ian Ford, Peter Cremer, Albert Hofman, Lars Wilhelmsen, Robert Clarke, Ian H. de Boer, J. Wouter Jukema, Alejandro Marin Ibanez, Debbie A. Lawlor, Ralph B. D'Agostino, Beatriz Rodriguez, Edoardo Casiglia, Coen D. A. Stehouwer, Leon A. Simons, Paul J. Nietert, Elizabeth Barrett-Connor, Demosthenes B. Panagiotakos, Cecilia Bjorkelund, Timo E. Strandberg, Sylvia Wassertheil-Smoller, Dan G. Blazer, James O. Taylor, Yoav Ben-Shlomo, George Davey Smith, Emerging Risk Factors Collaboration

Research output: Contribution to journal › Article (Academic Journal) › peer-review

211 Citations (Scopus)

Abstract

Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.

Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

Original language	English
Pages (from-to)	1419-1433
Number of pages	15
Journal	International Journal of Epidemiology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1093/ije/dys086
Publication status	Published - Oct 2012

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Wormser, D., Di Angelantonio, E., Kaptoge, S., Wood, A. M., Gao, P., Sun, Q., Walldius, G., Selmer, R., Verschuren, W. M. M., Bueno-de-Mesquita, H. B., Engstrom, G., Ridker, P. M., Njolstad, I., Iso, H., Holme, I., Giampaoli, S., Tunstall-Pedoe, H., Gaziano, J. M., Brunner, E., ... Emerging Risk Factors Collaboration (2012). Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. International Journal of Epidemiology, 41(5), 1419-1433. https://doi.org/10.1093/ije/dys086

@article{87283bdc798c4c39b49de3f96c2a34e0,

title = "Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis",

abstract = "Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.",

author = "David Wormser and {Di Angelantonio}, Emanuele and Stephen Kaptoge and Wood, {Angela M.} and Pei Gao and Qi Sun and Goeran Walldius and Randi Selmer and Verschuren, {W. M. Monique} and Bueno-de-Mesquita, {H. Bas} and Gunnar Engstrom and Ridker, {Paul M.} and Inger Njolstad and Hiroyasu Iso and Ingar Holme and Simona Giampaoli and Hugh Tunstall-Pedoe and Gaziano, {J. Michael} and Eric Brunner and Frank Kee and Alberto Tosetto and Christa Meisinger and Hermann Brenner and Pierre Ducimetiere and Whincup, {Peter H.} and Tipping, {Robert W.} and Ian Ford and Peter Cremer and Albert Hofman and Lars Wilhelmsen and Robert Clarke and {de Boer}, {Ian H.} and Jukema, {J. Wouter} and Ibanez, {Alejandro Marin} and Lawlor, {Debbie A.} and D'Agostino, {Ralph B.} and Beatriz Rodriguez and Edoardo Casiglia and Stehouwer, {Coen D. A.} and Simons, {Leon A.} and Nietert, {Paul J.} and Elizabeth Barrett-Connor and Panagiotakos, {Demosthenes B.} and Cecilia Bjorkelund and Strandberg, {Timo E.} and Sylvia Wassertheil-Smoller and Blazer, {Dan G.} and Taylor, {James O.} and Yoav Ben-Shlomo and {Davey Smith}, George and {Emerging Risk Factors Collaboration}",

year = "2012",

month = oct,

doi = "10.1093/ije/dys086",

language = "English",

volume = "41",

pages = "1419--1433",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "5",

}

Wormser, D, Di Angelantonio, E, Kaptoge, S, Wood, AM, Gao, P, Sun, Q, Walldius, G, Selmer, R, Verschuren, WMM, Bueno-de-Mesquita, HB, Engstrom, G, Ridker, PM, Njolstad, I, Iso, H, Holme, I, Giampaoli, S, Tunstall-Pedoe, H, Gaziano, JM, Brunner, E, Kee, F, Tosetto, A, Meisinger, C, Brenner, H, Ducimetiere, P, Whincup, PH, Tipping, RW, Ford, I, Cremer, P, Hofman, A, Wilhelmsen, L, Clarke, R, de Boer, IH, Jukema, JW, Ibanez, AM, Lawlor, DA, D'Agostino, RB, Rodriguez, B, Casiglia, E, Stehouwer, CDA, Simons, LA, Nietert, PJ, Barrett-Connor, E, Panagiotakos, DB, Bjorkelund, C, Strandberg, TE, Wassertheil-Smoller, S, Blazer, DG, Taylor, JO, Ben-Shlomo, Y , Davey Smith, G & Emerging Risk Factors Collaboration 2012, 'Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis', International Journal of Epidemiology, vol. 41, no. 5, pp. 1419-1433. https://doi.org/10.1093/ije/dys086

TY - JOUR

T1 - Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

AU - Wormser, David

AU - Di Angelantonio, Emanuele

AU - Kaptoge, Stephen

AU - Wood, Angela M.

AU - Gao, Pei

AU - Sun, Qi

AU - Walldius, Goeran

AU - Selmer, Randi

AU - Verschuren, W. M. Monique

AU - Bueno-de-Mesquita, H. Bas

AU - Engstrom, Gunnar

AU - Ridker, Paul M.

AU - Njolstad, Inger

AU - Iso, Hiroyasu

AU - Holme, Ingar

AU - Giampaoli, Simona

AU - Tunstall-Pedoe, Hugh

AU - Gaziano, J. Michael

AU - Brunner, Eric

AU - Kee, Frank

AU - Tosetto, Alberto

AU - Meisinger, Christa

AU - Brenner, Hermann

AU - Ducimetiere, Pierre

AU - Whincup, Peter H.

AU - Tipping, Robert W.

AU - Ford, Ian

AU - Cremer, Peter

AU - Hofman, Albert

AU - Wilhelmsen, Lars

AU - Clarke, Robert

AU - de Boer, Ian H.

AU - Jukema, J. Wouter

AU - Ibanez, Alejandro Marin

AU - Lawlor, Debbie A.

AU - D'Agostino, Ralph B.

AU - Rodriguez, Beatriz

AU - Casiglia, Edoardo

AU - Stehouwer, Coen D. A.

AU - Simons, Leon A.

AU - Nietert, Paul J.

AU - Barrett-Connor, Elizabeth

AU - Panagiotakos, Demosthenes B.

AU - Bjorkelund, Cecilia

AU - Strandberg, Timo E.

AU - Wassertheil-Smoller, Sylvia

AU - Blazer, Dan G.

AU - Taylor, James O.

AU - Ben-Shlomo, Yoav

AU - Davey Smith, George

AU - Emerging Risk Factors Collaboration

PY - 2012/10

Y1 - 2012/10

N2 - Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

AB - Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.Results For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

U2 - 10.1093/ije/dys086

DO - 10.1093/ije/dys086

M3 - Article (Academic Journal)

C2 - 22825588

SN - 0300-5771

VL - 41

SP - 1419

EP - 1433

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 5

ER -

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

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