Adult human mesenchymal cells proliferateand migrate in response to chemokines expressed in demyelination

CM Rice, NJ Scolding

Research output: Contribution to journalArticle (Academic Journal)peer-review

32 Citations (Scopus)

Abstract

Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC transplantation, although the mechanisms by which MSCs migrate to lesions and stimulate repair remain unknown. Chemokines stimulate migration in other settings. In this study, we systematically explore the migratory and proliferative responses of human MSCs (hMSC) to chemokines expressed in MS lesions. We demonstrate that these chemokines trigger hMSC migration. In addition, we show that RANTES and IP-10 promote hMSC proliferation.
Translated title of the contributionAdult human mesenchymal cells proliferateand migrate in response to chemokines expressed in demyelination
Original languageEnglish
Pages (from-to)235 - 240
Number of pages6
JournalCell Adhesion and Migration
Volume4(2)
DOIs
Publication statusPublished - Apr 2010

Fingerprint Dive into the research topics of 'Adult human mesenchymal cells proliferateand migrate in response to chemokines expressed in demyelination'. Together they form a unique fingerprint.

Cite this