Advanced paternal age: How old is too old?

IC Bray, D Gunnell, G Davey Smith

Research output: Contribution to journalArticle (Academic Journal)peer-review

187 Citations (Scopus)


Average paternal age in the UK is increasing. The public health implications of this trend have not been widely anticipated or debated. This commentary aims to contribute to such a debate. Accumulated chromosomal aberrations and mutations occurring during the maturation of male germ cells are thought to be responsible for the increased risk of certain conditions with older fathers. Growing evidence shows that the offspring of older fathers have reduced fertility and an increased risk of birth defects, some cancers, and schizophrenia. Adverse health outcomes should be weighed up against advantages for children born to older parents, mindful that these societal advantages are likely to change over time.
Translated title of the contributionAdvanced paternal age: How old is too old?
Original languageEnglish
Pages (from-to)851 - 853
Number of pages3
JournalJournal of Epidemiology and Community Health
Volume60 (10)
Publication statusPublished - Oct 2006

Bibliographical note

Publisher: BMJ Group


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