Advances and Surprises in a Decade of Oocyte Meiosis Research

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Eggs are produced from progenitor oocytes through meiotic cell division. Fidelity of meiosis is critical for healthy embryogenesis – fertilisation of aneuploid eggs that contain the wrong number of chromosomes is a leading cause of genetic disorders including Down’s syndrome, human embryo deaths and infertility. Incidence of meiosis-related oocyte and egg aneuploidies increases dramatically with advancing maternal age, which further complicates the ‘meiosis problem’. We have just emerged from a decade of meiosis research that was packed with exciting and transformative research. This minireview will focus primarily on studies of mechanisms that directly influence chromosome segregation.
Original languageEnglish
JournalEssays in Biochemistry
Publication statusPublished - 15 Jun 2020


  • aneuploidy
  • fertility
  • meiosis
  • microfilaments
  • microtubule
  • oocyte


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