Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

Lindsay Keir, Richard J M Coward

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)


Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor-A (VEGF-A).

Original languageEnglish
Pages (from-to)523 - 533
Number of pages11
JournalPediatric Nephrology
Issue number4
Publication statusPublished - Apr 2011


  • Humans
  • Kidney Glomerulus
  • Purpura, Thrombotic Thrombocytopenic
  • Thrombotic Microangiopathies
  • Vascular Endothelial Growth Factor A

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  • Projects

    MRC Award

    Coward , R. J. M.


    Project: Research

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